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Whether declining MOTS-c is a cause or consequence of this deterioration is still being resolved, but the correlation is striking enough that some researchers have proposed plasma MOTS-c as a biomarker of mitochondrial vitality and metabolic age

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While most of the 7.4 million individuals living with clinical Alzheimer's dementia and the estimated 4.2 million Americans with MCI due to Alzheimer's are 65 and older, research shows that physiological changes marking the earliest stages of Alzheimer's disease can begin up to 20 years before measurable cognitive impairment

Light scattering and the absolute characterization of macromolecules